… neonatal illness (3, 11). In line with this hypothesis, this study examined the impact of PF543
therapy during neonatal … characterizing the airway structure and AHR using murine model of …

… lung function and reduced airway remodeling as adults. This was … with D-sphingosine-ameliorated
hyperoxia-induced arrest of … Sphingosine Kinase 1 Inhibitor, PF543, ameliorates …

… hypertrophy were not seen in our murine model of acute asthma. Our 187 … , ameliorates
hyperoxia-induced airway remodeling in a murine 804 model of bronchopulmonary dysplasia. …

… Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced
airway remodeling in a murine model of bronchopulmonary dysplasia. Am J Physiol …

… Pharmacologic strategies to ameliorate or prevent BPD … Sphingosine Kinase 1 (Sphk1) is an
enzyme that catalyzes … , and reduce hyperoxia-induced lung injury in animal models. Citation…

… The S1P produced by sphingosine kinase 1 or 2 (SPHK1/… lung injury which was ameliorated
upon infusion with S1P [74,75]… the development of hyperoxia-induced neonatal murine lung …

… murine models of pulmonary fibrosis for assessing the protective effects of SPHK1 inhibition:
(1) … Further, we show that the protective effects of PF543 occur in part by ameliorating lung …

… Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced
airway remodeling in a murine model of bronchopulmonary dysplasia. American Journal …

… Hyperoxia-induced lung injury human lung microvascular … In an in vitro study, PF-543 (2
μM) ameliorated asbestos-… poor alveolar and airway remodeling, and is the most common …

… kinase (SPHK) is implicated in acute immunoresponses, however, … of bronchial asthma are
poorly understood. In this study, we hypothesized that SPHK inhibition could ameliorate lung …